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Brand name: toradol
Generic name: ketorolac tromethamine, Ketorolac

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This implies that the pharmacokinetics of ketorolac tromethamine in adults, following single or multiple IM, IV or recommended oral doses of TORADOL, are linear. Doses of TORADOL� IV/IM are not to exceed 60 mg (total dose per day) in these patients. This was particularly true in elderly patients who received an average daily dose greater than 60 mg/day of TORADOL (see Table 3A). There is a large T printed on both sides of the tablet, as well as the word TORADOL on one side, and the word ROCHE on the other. The adverse events seen with IV-administered TORADOL were similar to those observed with IM-administered TORADOL, as would be expected based on the similar pharmacokinetics and bioequivalence (AUC, clearance, plasma half-life) of IV and IM routes of TORADOL administration. The greatest difference between large and small doses of TORADOL by either route is in the duration of analgesia. Analgesia was significantly superior, at various postdosing pain assessment times, in the patients receiving TORADOL IV plus PCA morphine as compared to patients receiving PCA-administered morphine alone. 8 mg/kg IV injection of TORADOL in conjunction with morphine following orthopedic surgical procedures, compared to morphine alone. There are also insufficient data available to support the use of TORADOL ORAL in pediatric patients. Combined use of TORADOL IV/IM and TORADOL ORAL is not to exceed 5 days of use because of the potential of increasing the frequency and severity of adverse reactions associated with the recommended doses (see WARNINGS , PRECAUTIONS , DOSAGE AND ADMINISTRATION , and ADVERSE REACTIONS ). The majority of patients treated with either TORADOL or morphine were dosed for up to 3 days; a small percentage of patients received 5 days of dosing. There is limited data available to support the use of multiple doses of TORADOL IV/IM in pediatric patients.

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